• Therefore in this study we

  2018-11-09

  

  Therefore, in this study, we assessed the potential of iPSCs obtained from the peripheral blood of a proband of a TSC pedigree who presented with neurological abnormalities to develop a cellular model of TSC2 deficiency. pNSCs, neurons, and astrocytes were differentiated from the iPSCs to study the

• br As this takes place we have

  2018-11-09

  

  As this takes place, we have an easily testable relation meaning that it does not particularly matter in which order the independent regressors and the independent response components are lined when takes the diagonal form. With the OLS estimate and the mutual covariance matrix of the vector co

• Our study has focused on charged particle fluxes

  2018-11-09

  

  Our study has focused on charged particle fluxes in a small neighborhood of the plane of symmetry, which allowed approximately calculating the spatial distribution of the field structure; for this we employed the well-known expansion in powers of the small quantity z: The study in the degree of a

• br The corresponding number of trajectories is ten at

  2018-11-09

  

  The corresponding number of trajectories is ten at h=3d= 1.2mm, and the ‘useful’ area increases: After choosing relative position of the emitter and lens end, calculations were done of how to transport and focus the beam by the lens. It was again implemented with the use of the program ‘Simion7

• Individual level studies of sense of place have

  2018-11-09

  

  Individual-level studies of sense of place have lacked conceptual cohesion, coming under various guises including ‘place attachment’ (Hidalgo & Hernandez, 2001; Scannell & Gifford, 2010), ‘sense of community’ (Gattino et al., 2013), and ‘sense of place’ (Pretty, Chipuer, & Bramston, 2003; Williams &

• br Conflicts of Interest br Author

  2018-11-09

  

  Conflicts of Interest Author Contributions Acknowledgments This work was supported by a Grant-in-Aid for Scientific Research (KAKENHI) from the Japan Society for the Promotion of Science (JSPS) and the Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT) (Grant num

• We explored temporal patterns of the

  2018-11-09

  

  We explored temporal patterns of the temperature-outcome relationship (lags) for all diseases (Supplementary File 7). We pooled heat effects as a) lag 0, 1 and 0–1, and b) above lag 2, and cold effects as a) lag 15. The risk for heat-related CVD mortality was greatest for lag 0–1; 4.15% (3.7–4.59) r

• Further study will be necessary to fully elucidate

  2018-11-09

  

  Further study will be necessary to fully elucidate the epidemiology of in vitro and in vivo susceptibility to β-lactam/β-lactamase inhibitor combinations globally and in other lineages of M. tuberculosis. The association between MDR and XDR clinical isolates and in vitro susceptibility to amoxicilli

• With conservative fuel savings of

  2018-11-09

  

  With conservative fuel savings of 35% observed in the laboratory, one BDS will save about 4kg of CO2-e from entering the buy tropisetron per day and will pay off its embodied CO2-e within a week of use (assuming 1:1 replacement of the TSF). At a cost of $20 per stove and a $0.97 per day fuel saving

• Metaplasticity is the dynamic regulation of the

  2018-11-09

  

  Metaplasticity is the dynamic regulation of the ability to induce activity-dependent synaptic plasticity and is governed by the prior history of activity (i.e. the plasticity of synaptic plasticity, Abraham and Bear, 1996). In empirical tests, synaptic metaplasticity is commonly defined as a shift i

• The general principles of dynamic systems theory may be usef

  2018-11-09

  

  The general principles of dynamic systems theory may be useful for conceptualizing biological self-organization. The first such principle is the tenet of multicausality, which assumes that the regularities of the mature organism patently emerge from multiple factors, including internal configuration

• The anatomical differences found between the Chinese and U

  2018-11-09

  

  The anatomical differences found between the Chinese and U.S. child templates parallel the findings of hematoxylin differences between these two developmental populations from previous research. For example, Guo et al. (2007) found different trajectory of GM development between Chinese and U.S. chi

• To date a variety of

  2018-11-09

  

  To date, a variety of surface chemistries have been proposed to facilitate the covalent immobilization of biomolecules onto paper, such as divinyl sulfone chemistry, diazonium chemistry or polymer chemistry [12–14]. Among them, long-chain and flexible polysaccharides with multiple functional groups

• During summers and winters in Antarctica

  2018-11-09

  

  During summers and winters in Antarctica, the most extreme and isolated continent on earth, the human circadian clock cannot rely on changes of photoperiod and temperature to entrain the clock day after day, and circadian rhythms might tend to free run [17]. Sleep disorders reported in Antarctic cre

• br Conflict of interest br Acknowledgements This work was fu

  2018-11-09

  

  Conflict of interest Acknowledgements This work was funded by King Abdulaziz University, under Grant no. (D-004/431). The authors, therefore, acknowledge technical and financial support of KAU, Saudi Arabia. Introduction Inverse problems is a branch of research whose scope can be broadly d

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