• br Material and methods br Results

  2018-11-08

  

  Material and methods Results Discussion Aging-associated phenotype change in hBMSCs is one of the most important considerations in furthering the advancement of cell-based therapy and is a subject of numerous studies and reviews (Baker et al., 2015; Bara et al., 2014). In regard to the in v

• br Materials and methods br

  2018-11-08

  

  Materials and methods Author disclosure statement Acknowledgments We are grateful to Prof. Angel Raya for his help and advice with iPS cell generation. This work was supported by grants from the “Centro de Investigación Biomédica en Red en Enfermedades Raras” (CIBERER) (grant 13-717/132.05

• The catenindependent Wnt signaling pathway is also important

  2018-11-08

  

  The β-catenindependent Wnt signaling pathway is also important in the modulation of cell proliferation, cell survival, and embryo development [74–76] and is also identified as a regulator of stem cell fate determination [77,78]. It was found that phosphorylation levels of c-Myc and β-catenin (target

• We exploited the fact that

  2018-11-08

  

  We exploited the fact that the eHBs were trapped as progenitors to analyze the effect of specific growth factors upon them and uncovered a central role for FGF (Figure 6). These data are consistent with studies in which FGF promoted the expansion of BL-CFCs derived from human or murine ESCs (Faloon

• br Author Contributions br Acknowledgments br Introduction

  2018-11-08

  

  Author Contributions Acknowledgments Introduction Alpha-1 antitrypsin deficiency (AATD) is a common genetic cause of both liver and lung disease affecting an estimated 3.4 million patients worldwide (de Serres, 2002). The most common disease variant is caused by an inherited single lenvatin

• br Material and methods br Results br Discussion CHI usually

  2018-11-08

  

  Material and methods Results Discussion CHI usually results in severe and permanent neurological impairment. However, there is no single effective therapy for neurological deficits (Kumar and Loane, 2012). Additionally, there is no single animal model reproducing the entire spectrum of neur

• In the dermis the glial P NGFR positive BC

  2018-11-08

  

  In the dermis, the glial P75NGFR-positive BC derivatives also include a neurogenic and gliogenic stem-like cell population. Multipotent stem-like cell populations have been described previously in the adult trunk skin, associated with the glial and melanocyte lineages and derived from the NC (Wong e

• During differentiation mitochondrial maturation requires a d

  2018-11-07

  

  During differentiation, mitochondrial maturation requires a dynamic network and a continuous balance between fission and fusion processes. The balance is maintained via quality control of mitochondrial fission and fusion proteins. Drp1 (Yoon et al., 2003), a key mitochondria protein controlling fiss

• br Introduction Ocimum basilicum O basilicum Linn popularly

  2018-11-07

  

  Introduction Ocimum basilicum (O. basilicum) Linn., popularly known as sweet basil in English, “Tulsi” in Hindi and “Raihan” in Arabic, belongs to the family Lamiaceae. It is an annual herb that is widely grown as a commercial ornamental crop in tropical and warm temperate regions of the world in

• Combining Eq with an observation equation Eq we

  2018-11-07

  

  Combining Eq. (20) with an observation equation (Eq. (15)), we have a state space model with Markov switching:where and Markov states and are independent with transition matrices and , respectively. Therefore, the solution method proposed by Farmer et al. (2008) allows rewriting the MS-DSGE mod

• br Role of Sponsors br Author Contributions br Conflicts

  2018-11-07

  

  Role of Sponsors Author Contributions Conflicts of Interest Acknowledgments Introduction Chronic obstructive pulmonary disease (COPD) remains a major cause of morbidity and mortality worldwide. This will be the third cause of deaths worldwide in 2020 according to the WHO. COPD is a lu

• According to HCV status we found a stronger association betw

  2018-11-07

  

  According to HCV status, we found a stronger association between low TGF-β1 concentrations and the risk of death from HCC among the HCV-positive group compared to the HCV-negative group, suggesting that the predictive value of TGF-β1 is more potent in higher risk HCV-positive individuals. This findi

• PFI 3 Elastase is released from azurophilic granules in the

  2018-11-07

  

  Elastase is released from azurophilic granules in the neutrophil cytoplasm. Ultramorphology of an area of unaffected tissue in a kidney removed from a patient with renal cancer demonstrated the passage of neutrophils through glomerular PFI 3 where elastase was released from granules onto the adjac

• To address these knowledge gaps in the pathogenesis of

  2018-11-07

  

  To address these knowledge gaps in the pathogenesis of TBI, we conducted a comprehensive systems biology study (Fig. 1) focusing on the impact of concussive injury on fundamental gene regulatory mechanisms. Unlike previous studies based on microarrays (von Gertten et al., 2005; Rojo et al., 2011; Sa

• prostanoid receptors br Funding This work was funded by

  2018-11-07

  

  Funding This work was funded by the National Institutes of Health (NIH)/National Institute of Allergy and Infectious Diseases (NIAID) contract HHSN272200800047C to EP. The Kawempe Community Health Study was funded entirely by the Tuberculosis Research Unit (grant N01-AI95383 and HHSN266200700022C

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