• br Mechanisms of anticancer drug resistance

  2018-10-25

  

  Mechanisms of anticancer drug resistance Tumor resistance to anticancer drug was a well-known clinical phenomenon that was yielding its secrets to investigation at the molecular level. It was important to validate the important mechanisms from the resistance situation of the patient. Table 2 show

• br Homologous recombination donor system and targeting

  2018-10-24

  

  Homologous recombination: donor system and targeting strategy Classic protocols for gene targeting through HR recommend the use of donor plasmids containing a selection cassette between two homologous arms of several hundred up to several thousand bp. In addition to antibiotic resistance markers

• A niche is defined as

  2018-10-24

  

  A niche is defined as a microenvironment that maintains stem ibuprofen msds through growth factors, cell surface proteins and extracellular matrices (ECMs), and is identified in some organs such as the intestine, brain, skeletal muscle, skin and testis (Chen and Chuong, 2012; Gattazzo et al., 2014;

• br Materials and methods br

  2018-10-24

  

  Materials and methods Acknowledgments We would like to thank Dr. Keisuke Okita and Prof. Shinya Yamanaka for providing the comt inhibitor for reprogramming. We thank I Bente Smith Thorup for excellent technical assistance in the cell culture. We thank Jeannette Schoene and Dirk A. Pflumm for

• br Results br Discussion Adrenergic receptors

  2018-10-24

  

  Results Discussion α-Adrenergic receptors play a critical role in the regulation of cellular growth pathways, including hypertrophy and proliferation. G protein-coupled α1ARs are the predominant α-adrenergic subtype in the myocardium of most species (Brückner et al., 1985), and catecholamine r

• The dynamic clonal behavior and conversion of

  2018-10-24

  

  The dynamic clonal behavior and conversion of leukemic ochratoxin a that we observed in our mouse model show resemblance with patients presenting with leukemic relapse after treatment. First, if remissions in relapsed patients are treated similarly as the original leukemia, the response is often di

• Previously in vitro studies of CIPN were

  2018-10-24

  

  Previously, in vitro studies of CIPN were performed in rat pheochromocytoma or SK-N-SH human neuroblastoma cell lines as model systems to evaluate decreases in neurite outgrowth in response to neurotoxic chemotherapy drugs, such as paclitaxel, vincristine, oxaliplatin and cisplatin (Rovini et al.,

• Although we followed all of the rules

  2018-10-24

  

  Although we followed all of the rules, we hesitate to use the phrase cGMP-compliant because this is a determination that will ultimately be made by the regulatory authorities when the entire IND package is provided to the FDA. We also note that the approval of the use of this line as part of an IND

• br Experimental Procedures Murine ESC lines E Tg A

  2018-10-24

  

  Experimental Procedures Murine ESC lines E14Tg2A (passages 25–38) and K/l EB5 (transgenic Rax-GFP ESCs, used with the kind permission of Y. Sasai, RIKEN Center) and H9 hESCs (WiCell) were cultured as described (Bertacchi et al., 2013; Lupo et al., 2013). All animal protocols were reviewed and app

• The correct deposition of m C into RNAs is essential

  2018-10-24

  

  The correct deposition of m5C into RNAs is essential for normal development. Loss-of-function mutations in the NSUN2 gene in both mouse and human cause growth retardation and neurodevelopmental deficits including microcephaly, as well as defects in cognition and motor function (Blanco and Frye, 2014

• MET is an important step in reprogramming

  2018-10-24

  

  MET is an important step in reprogramming fibroblasts to iPSCs (Li et al., 2010; Samavarchi-Tehrani et al., 2010), and the acquisition of epithelial features and loss of mesenchymal features are known to occur soon after transfection with Yamanaka factors (David and Polo, 2014; Polo et al., 2012). T

• br Background br Methods br

  2018-10-24

  

  Background Methods Results Discussion The hypotheses and whether they were supported are summarized in Table 6. The results indicate that, contrary to prior research on health generally or negative health behaviors such as smoking, own unemployment is not associated with negative changes

• The analysis here has important

  2018-10-24

  

  The analysis here has important limitations. Many of the policy decisions that would help to constrain unnecessary medical spending lie outside of the control of the California State government. Some, like a law compelling price transparency for pharmaceuticals and medical procedures, are within rel

• br Funding This work was supported by the

  2018-10-24

  

  Funding This work was supported by the Swedish Research Council for Health, Working Life and Welfare (FORTE) under Grant number 2014-0445 for Jenny Torssander, and by the University of Copenhagen for Laust H Mortensen. Body Reports of disrespectful maternity care are emerging worldwide, despi

• We acknowledge several other limitations in our study First

  2018-10-24

  

  We acknowledge several other limitations in our study. First, as we have indicated, there was some selective attrition from the sample between the two interviews. This is not uncommon in panel studies, especially those in which older adults are interviewed (Li et al., 2005). Second, while we have at

15287 records 1015/1020 page Previous Next First page 上5页 10111012101310141015 下5页 Last page