• It seems that D R

  2018-10-22

  

  It seems that D1R improves HSC transplantation likely through affecting both HSCs and their niches. Activation of Notch signaling in HSCs by D1R bound to ECs might promote HSC expansion principally through their enhanced proliferation, and decreased apoptosis might also contribute to the ex vivo exp

• Mesenchymal stem cells MSCs can be isolated from various

  2018-10-20

  

  Mesenchymal stem withaferin a (MSCs) can be isolated from various adult tissues (including bone marrow), they are multipotent and can differentiate into cells of the mesodermal (e.g. adipocytes, osteocytes, chondrocytes) as well as other embryonic lineages (Jiang et al., 2002). MSCs can also be cul

• Experiments in NHPs can also be more technically challenging

  2018-10-20

  

  Experiments in NHPs can also be more technically challenging than those carried out in rodents. For example, MPTP is a highly toxic reagent and animals exposed to it need to be housed in biosafety level 2 laboratories and cared for by highly trained staff. Further, although a stereotactic atlas does

• br Resource table Resource details The study was approved

  2018-10-20

  

  Resource table. Resource details The study was approved by the Singhealth ethics committee (protocol number SHSIBC-2014-031), and written informed consent was obtained from the patient. 2ml of peripheral blood sample was obtained from a male 64-year-old Parkinson\'s disease patient carrying a he

• br Acknowledgments br Introduction Expression of

  2018-10-20

  

  Acknowledgments Introduction Expression of a defined set of transcription factors (OCT4, SOX2, KLF4, and c-MYC) reprograms human somatic cells to a pluripotent state, generating induced pluripotent stem cells (iPSCs) (Park et al., 2008b; Takahashi et al., 2007; Yu et al., 2007). iPSCs are simi

• glutamate receptor Determining whether the specification of

  2018-10-20

  

  Determining whether the specification of most, or all, cell lineages occurs within neoblasts is essential for understanding the cellular basis for planarian regeneration. Specifically, at what cellular step in regeneration is the identity of new glutamate receptor specified? On the basis of prior r

• Tracking the maturation status of stem cell derived cardiac

  2018-10-20

  

  Tracking the maturation status of stem cell-derived cardiac myocytes by ratiometric analysis of the cTnI:ssTnI protein profile provides a tool to permit direct comparisons of myocyte developmental status from different cell lines and with using different culture methods and differentiation protocol

• Previously our group has isolated human embryonic stem

  2018-10-20

  

  Previously, our group has isolated human embryonic stem methane monooxygenase (ESCs) whose pluripotent state is maintained in vitro by exogenous growth factor signaling, particularly fibroblast growth factor (FGF), insulin or insulin-like growth factor, and transforming growth factor (Bendall et al

• Recent reports have had success with promoting

  2018-10-20

  

  Recent reports have had success with promoting differentiation of PSC first to NKX2-1+ lung progenitor order RG7388 and further to airway (Gilpin et al., 2014; Gouon-Evans et al., 2006; Huang et al., 2014; Kubo et al., 2004; Mou et al., 2012; Wong et al., 2012) or alveolar (Ghaedi et al., 2013; Hua

• br Experimental Procedures br Acknowledgments br Introductio

  2018-10-20

  

  Experimental Procedures Acknowledgments Introduction Articular cartilage covers the ends of bones and provides shock aldose reductase inhibitors and lubrication to diarthrodial joints. Articular cartilage is a highly specialized tissue composed of chondrocytes and a specific extracellular m

• Using a chemically defined monolayer neural differentiation

  2018-10-20

  

  Using a chemically defined, monolayer neural differentiation system (Lippmann et al., 2014), we determined that by temporally modulating Wnt/β-catenin and FGF signaling, hPSCs could be differentiated into pure SOX2+/Brachyury+ NMPs that were stable for 7 days. Over this period, the NMPs exhibited co

• Introduction Adipose stromal progenitor cells

  2018-10-20

  

  Introduction Adipose stromal/progenitor Sitagliptin phosphate monohydrate (ASCs) are the major reservoir of adipocyte precursors and are crucial for adipose tissue renewal, homeostasis and expansion (Berry et al., 2016; Rodeheffer et al., 2008; Tang et al., 2008; Yamamoto et al., 2007). In white a

• Acute and transient MF activation

  2018-10-20

  

  Acute and transient MF activation is part of the body’s normal wound healing program, but persistent MFs contribute to fibrosis by excessively producing and contracting collagenous extracellular matrix (ECM) into stiff scar tissue (Hinz et al., 2012). In turn, the stiffness of mature scar promotes m

• In vitro we demonstrated that the DMR can drive luciferase

  2018-10-20

  

  In vitro, we demonstrated that the DMR can drive luciferase expression in three different cell lines (293T,COS-7, and HepG2) and markedly enhances reporter gene activity (10- to 15-fold increase) compared with basal activity obtained with either the SIX5 promoter, the entire region that surrounds th

• Because Q SA and Q SC represent an

  2018-10-20

  

  Because Q3SA and Q3SC represent an isogenic pair of iPSC lines from the same individual but with contrasting ATM genotypes (ATM−/− versus ATM+/−, respectively), we examined gene expression differences using RNA sequencing (RNA-seq), evaluating matches at the transcript level. Relatively few mRNAs we

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