In vitro we demonstrated that the DMR can drive luciferase

2018-10-20

In vitro, we demonstrated that the DMR can drive luciferase expression in three different cell lines (293T,COS-7, and HepG2) and markedly enhances reporter gene activity (10- to 15-fold increase) compared with basal activity obtained with either the SIX5 promoter, the entire region that surrounds th

Because Q SA and Q SC represent an

2018-10-20

Because Q3SA and Q3SC represent an isogenic pair of iPSC lines from the same individual but with contrasting ATM genotypes (ATM−/− versus ATM+/−, respectively), we examined gene expression differences using RNA sequencing (RNA-seq), evaluating matches at the transcript level. Relatively few mRNAs we

The impairment of cardiac differentiation resulting from Cit

2018-10-20

The impairment of cardiac differentiation resulting from Cited2 depletion at the onset of ESC differentiation may be due to a consequent downregulation of Brachyury and Mesp1 expression. The decrease of Isl1, Nkx2.5, Gata4, and Tbx5 expression that we observed in Cited2-depleted cells at D5 of diffe

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2018-07-29