• It has been shown that in several cancers

  2018-11-12

  

  It has been shown that, in several cancers, only a minority of the cancer NMS-873 Supplier are able to initiate the formation of new tumors. These cancer-initiation cells are called CSCs, and in several studies the CD44 adhesion molecule has been demonstrated to be expressed specifically in these c

• Previously we have demonstrated that AT

  2018-11-12

  

  Previously we have demonstrated that AT-MSCs express enzymes relevant for the intracellular metabolism of 5FU such as thymidylate synthase (TS), thymidylate phosphorylase (TP), orotate phosphoribosyltransferase (OPRT) and dihydropyrimidine dehydrogenase (DPD) (Kucerova et al., 2008). DPD rapidly deg

• diacylglycerol kinase In some neurodegenerative diseases suc

  2018-11-12

  

  In some neurodegenerative diseases such as AD, PD and amyotrophic lateral sclerosis, ectopic diacylglycerol kinase events (CCEs) have been observed in post-mitotic neurons (Bonda et al., 2009; Lim and Qi, 2003; Ranganathan and Bowser, 2003; Smith et al., 2004). In the 1990s, several groups reported

• br Experimental Procedures Human fetal tissues were obtained

  2018-11-12

  

  Experimental Procedures Human fetal tissues were obtained from Novogenix Laboratories following informed consent and elective termination. Developmental age was determined by ultrasound. Adult articular chondrocytes and synovial membrane were obtained from National Disease Research Interchange. P

• Thus with these data we assert that small replicating

  2018-11-12

  

  Thus, with these data we assert that small replicating cells do not “become” large replicating cells upon culture expansion of BMSCs. Nor are those large cells “old”, in the sense that these cells are from earlier generations that gradually increase in cell size with time in vitro. Rather, large cel

• URB597 Another practical advantage of the system is its rel

  2018-11-12

  

  Another practical advantage of the system is its relative low cost. The high price of current commercially available serum-free media such as StemPro and mTeSR always hinders the universal application of the scale-up technologies for hiPSC expansion, especially for xeno-free media when albumin is re

• Our group recently reported a

  2018-11-12

  

  Our group recently reported a model system, which allows to effectively screen whole miRNA libraries for miRNA candidates modulating reprogramming efficacy (Pfaff et al., 2011). Utilizing this model, we previously have identified a miRNA family consisting of miR-130b, miR-301b, and miR-721 strongly

• In our prior studies we showed that K

  2018-11-12

  

  In our prior studies, we showed that K-RasG12D promotes proliferation in the intestinal epithelium by activating MEK, but that K-RasG12D promotes proliferation of colorectal cancer Quizartinib Supplier through a MEK-independent mechanism (Haigis et al., 2008). To determine whether K-RasG12D promote

• Our gene chip analysis also revealed a robust upregulation

  2018-11-09

  

  Our gene chip analysis also revealed a robust upregulation of metallothionein (MT) family members that are involved in metal metabolism and detoxification, as well as reactive oxygen species (ROS) scavenging. Overexpression of MT has been shown to protect mice from streptozotocin (STZ)-induced β cel

• An important yet unanswered question in ALS disease pathophy

  2018-11-09

  

  An important yet unanswered question in ALS disease pathophysiology is the targeted loss of MNs but relative sparing of non-MNs. Strikingly, we found that the AP1 complex member JUN was expressed at significantly higher levels in MNs compared with non-MNs, suggesting a role of JUN in maintaining MN

• Therefore in this study we

  2018-11-09

  

  Therefore, in this study, we assessed the potential of iPSCs obtained from the peripheral blood of a proband of a TSC pedigree who presented with neurological abnormalities to develop a cellular model of TSC2 deficiency. pNSCs, neurons, and astrocytes were differentiated from the iPSCs to study the

• br As this takes place we have

  2018-11-09

  

  As this takes place, we have an easily testable relation meaning that it does not particularly matter in which order the independent regressors and the independent response components are lined when takes the diagonal form. With the OLS estimate and the mutual covariance matrix of the vector co

• Our study has focused on charged particle fluxes

  2018-11-09

  

  Our study has focused on charged particle fluxes in a small neighborhood of the plane of symmetry, which allowed approximately calculating the spatial distribution of the field structure; for this we employed the well-known expansion in powers of the small quantity z: The study in the degree of a

• br The corresponding number of trajectories is ten at

  2018-11-09

  

  The corresponding number of trajectories is ten at h=3d= 1.2mm, and the ‘useful’ area increases: After choosing relative position of the emitter and lens end, calculations were done of how to transport and focus the beam by the lens. It was again implemented with the use of the program ‘Simion7

• Individual level studies of sense of place have

  2018-11-09

  

  Individual-level studies of sense of place have lacked conceptual cohesion, coming under various guises including ‘place attachment’ (Hidalgo & Hernandez, 2001; Scannell & Gifford, 2010), ‘sense of community’ (Gattino et al., 2013), and ‘sense of place’ (Pretty, Chipuer, & Bramston, 2003; Williams &

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