• Introduction Programmable nucleases are seeing widespread

  2018-11-02

  

  Introduction Programmable nucleases are seeing widespread application in the genome engineering field on account of their ability to permit precise genetic modifications in cell cultures and whole organisms. The CRISPR/Cas9 (CRISPR-associated) system (Bhaya et al., 2011) has attracted particular at

• We suggest two interconnected approaches to solve these prob

  2018-11-02

  

  We suggest two interconnected approaches to solve these problems: The following types of results are discussed: The traditional model and the flow distribution problem The traditional model of steady isothermal flow distribution in a HC includes Kirchhoff\'s laws and closing relations: where

• br Acknowledgment br This work was supported by the

  2018-11-02

  

  Acknowledgment This work was supported by the Ministry of Science and Education of the Russian Federation (Program 3.329.2014/K). According to Kotelnikov\'s works , normal fluctuation noise consists of a large number of pulses following each other in random time intervals; it Tubastatin A m

• Analysts may empirically check if the

  2018-11-02

  

  Analysts may empirically check if the outcome variable has an ICC that O4I1 cost is distinguishable from zero, as introduced briefly above. Even those favoring a priori specification of how the model will account for clustering, coauthor or reviewer suggestions may warrant an empirically-informed r

• Table shows results from models

  2018-11-02

  

  Table 4 shows results from models partitioned by sex. In Amyloid β-Peptide (1-42) to the pooled results, Model 2 of Table 4, our fully adjusted model, shows no statistically significant difference in the probability of being a current smoker among the first generation males in the sample by age at m

• However this explanation of stress as a direct cause

  2018-11-02

  

  However, this explanation of stress as a direct cause of social disparities in physical health does not account for the fact that socially-disadvantaged groups, particularly African Americans and Hispanics in the US, despite having higher morbidity and mortality, have better mental health relative t

• Recently studies about temperature rhythm

  2018-11-01

  

  Recently, studies about temperature rhythm have also been improved with the development of a wireless system for continuous measurement of human skin temperature, allowing the longitudinal recording of peripheral temperature. Areas et al. [11] described its use in a chronobiological study, suggestin

• In this study the prepared D layer by layer graphene

  2018-11-01

  

  In this study, the prepared 3D layer-by-layer graphene-GNR hybrid nanomaterial was coated on a thick film screen-printed active carbon powder electrode as a single-use, disposable biosensor for testing H2O2. The performance of GNR without supporting graphene layers was tested for comparison through

• br Introducci n La discusi

  2018-11-01

  

  Introducción La discusión sobre el salario mínimo es altamente controversial. Uno de los ejemplos favoritos en cursos introductorios de Economía es mostrar cómo el salario mínimo causa desempleo. De hecho, sin necesidad de tomar un curso de economía, la intuición a primera vista pareciera mostar

• Sin embargo no han cambiado las cosas con la

  2018-11-01

  

  Sin embargo, ¿no han cambiado las cosas con la “Nueva Geografía Económica” que según su representante más conocido, Paul Krugman (1998, 7), “serves the important purpose of placing geographical analysis squarely in the economic mainstream”? Los geógrafos, por lo menos, se muestran poco convencidos.

• To date smallpox is the only infectious

  2018-11-01

  

  To date, smallpox is the only infectious disease of humans that has been eradicated. A biological factor that favored smallpox eradication is the lack of a nonhuman reservoir. In glycogen phosphorylase to smallpox, a yaws-like disease has been documented in various species of nonhuman primates (NHP

• br Material and Methods br Results br

  2018-11-01

  

  Material and Methods Results Discussion Our analysis of cancer-related mutations associated with MUTYH inactivation in MAP reveals that the absence of MUTYH-mediated processing of 8-oxoG:A mispairs results in a relatively modest mutator phenotype. The increase in mutation rates in MAP CRC i

• The findings of Liang and

  2018-11-01

  

  The findings of Liang and co-workers add to current knowledge on gastric and colorectal carcinogenesis, uncovering the cooperation between deranged genetic and epigenetic mechanism in two extensively studied tumor models. In addition, novel CRC prognostic biomarkers might allow for improved patient

• br Acknowledgments The data was

  2018-11-01

  

  Acknowledgments The data was collected with funding from the East Carolina University Department of Economics. Ju-Chin Huang collaborated with the author on the survey design. Value of the data Materials and methods Specifications table Data, experimental design, materials and methods

• Oversized preliminary clusters were selected for subsequent

  2018-11-01

  

  Oversized preliminary clusters were selected for subsequent splitting by agglomerative hierarchical clustering based on a criterion of (mean number of marked minutiae per examiner) >1.5. This arbitrary threshold was selected because (1) automated splitting of clusters meeting this criterion was high

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