• No effective therapies are available for motor neuron diseas

  2018-11-02

  

  No effective therapies are available for motor neuron diseases, including SMARD1. Neural stem cell (NSC) transplantation represents a possible therapeutic strategy for ameliorating the neurological phenotype by multiple mechanisms, including neuroprotection and cell replacement of different CNS neur

• hsp90 inhibitors Whereas most studies aiming at reprogrammin

  2018-11-02

  

  Whereas most studies aiming at reprogramming brain-resident glia into neurons focused on astroglia, NG2 glia represent an interesting alternative cellular source given their abundance and life-long capacity for proliferation (Dimou and Götz, 2014). Here, we found that ∼60% of the induced DCX+ neuron

• Here we sought to identify new druggable therapeutic targets

  2018-11-02

  

  Here, we sought to identify new druggable therapeutic targets for GBM. We combined transcriptome expression profiling and loss-of-function approaches to identify human kinases that play differential roles in PN and/or MES GSCs. Using a human kinome-wide lentiviral shRNA library, we identified 82 can

• Previous studies have reported that

  2018-11-02

  

  Previous studies have reported that Notch signaling controls the induction of neural stem ack1 inhibitor in vitro and in vivo during differentiation (Crawford and Roelink, 2007; Nelson et al., 2007). As established by Ogura et al. (2013), inhibition of this signaling pathway promotes the neuronal d

• Introduction Programmable nucleases are seeing widespread

  2018-11-02

  

  Introduction Programmable nucleases are seeing widespread application in the genome engineering field on account of their ability to permit precise genetic modifications in cell cultures and whole organisms. The CRISPR/Cas9 (CRISPR-associated) system (Bhaya et al., 2011) has attracted particular at

• We suggest two interconnected approaches to solve these prob

  2018-11-02

  

  We suggest two interconnected approaches to solve these problems: The following types of results are discussed: The traditional model and the flow distribution problem The traditional model of steady isothermal flow distribution in a HC includes Kirchhoff\'s laws and closing relations: where

• br Acknowledgment br This work was supported by the

  2018-11-02

  

  Acknowledgment This work was supported by the Ministry of Science and Education of the Russian Federation (Program 3.329.2014/K). According to Kotelnikov\'s works , normal fluctuation noise consists of a large number of pulses following each other in random time intervals; it Tubastatin A m

• Analysts may empirically check if the

  2018-11-02

  

  Analysts may empirically check if the outcome variable has an ICC that O4I1 cost is distinguishable from zero, as introduced briefly above. Even those favoring a priori specification of how the model will account for clustering, coauthor or reviewer suggestions may warrant an empirically-informed r

• Table shows results from models

  2018-11-02

  

  Table 4 shows results from models partitioned by sex. In Amyloid β-Peptide (1-42) to the pooled results, Model 2 of Table 4, our fully adjusted model, shows no statistically significant difference in the probability of being a current smoker among the first generation males in the sample by age at m

• However this explanation of stress as a direct cause

  2018-11-02

  

  However, this explanation of stress as a direct cause of social disparities in physical health does not account for the fact that socially-disadvantaged groups, particularly African Americans and Hispanics in the US, despite having higher morbidity and mortality, have better mental health relative t

• Recently studies about temperature rhythm

  2018-11-01

  

  Recently, studies about temperature rhythm have also been improved with the development of a wireless system for continuous measurement of human skin temperature, allowing the longitudinal recording of peripheral temperature. Areas et al. [11] described its use in a chronobiological study, suggestin

• In this study the prepared D layer by layer graphene

  2018-11-01

  

  In this study, the prepared 3D layer-by-layer graphene-GNR hybrid nanomaterial was coated on a thick film screen-printed active carbon powder electrode as a single-use, disposable biosensor for testing H2O2. The performance of GNR without supporting graphene layers was tested for comparison through

• br Introducci n La discusi

  2018-11-01

  

  Introducción La discusión sobre el salario mínimo es altamente controversial. Uno de los ejemplos favoritos en cursos introductorios de Economía es mostrar cómo el salario mínimo causa desempleo. De hecho, sin necesidad de tomar un curso de economía, la intuición a primera vista pareciera mostar

• Sin embargo no han cambiado las cosas con la

  2018-11-01

  

  Sin embargo, ¿no han cambiado las cosas con la “Nueva Geografía Económica” que según su representante más conocido, Paul Krugman (1998, 7), “serves the important purpose of placing geographical analysis squarely in the economic mainstream”? Los geógrafos, por lo menos, se muestran poco convencidos.

• To date smallpox is the only infectious

  2018-11-01

  

  To date, smallpox is the only infectious disease of humans that has been eradicated. A biological factor that favored smallpox eradication is the lack of a nonhuman reservoir. In glycogen phosphorylase to smallpox, a yaws-like disease has been documented in various species of nonhuman primates (NHP

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