• Previously in vitro studies of CIPN were

  2018-10-24

  

  Previously, in vitro studies of CIPN were performed in rat pheochromocytoma or SK-N-SH human neuroblastoma cell lines as model systems to evaluate decreases in neurite outgrowth in response to neurotoxic chemotherapy drugs, such as paclitaxel, vincristine, oxaliplatin and cisplatin (Rovini et al.,

• Although we followed all of the rules

  2018-10-24

  

  Although we followed all of the rules, we hesitate to use the phrase cGMP-compliant because this is a determination that will ultimately be made by the regulatory authorities when the entire IND package is provided to the FDA. We also note that the approval of the use of this line as part of an IND

• br Experimental Procedures Murine ESC lines E Tg A

  2018-10-24

  

  Experimental Procedures Murine ESC lines E14Tg2A (passages 25–38) and K/l EB5 (transgenic Rax-GFP ESCs, used with the kind permission of Y. Sasai, RIKEN Center) and H9 hESCs (WiCell) were cultured as described (Bertacchi et al., 2013; Lupo et al., 2013). All animal protocols were reviewed and app

• The correct deposition of m C into RNAs is essential

  2018-10-24

  

  The correct deposition of m5C into RNAs is essential for normal development. Loss-of-function mutations in the NSUN2 gene in both mouse and human cause growth retardation and neurodevelopmental deficits including microcephaly, as well as defects in cognition and motor function (Blanco and Frye, 2014

• MET is an important step in reprogramming

  2018-10-24

  

  MET is an important step in reprogramming fibroblasts to iPSCs (Li et al., 2010; Samavarchi-Tehrani et al., 2010), and the acquisition of epithelial features and loss of mesenchymal features are known to occur soon after transfection with Yamanaka factors (David and Polo, 2014; Polo et al., 2012). T

• br Background br Methods br

  2018-10-24

  

  Background Methods Results Discussion The hypotheses and whether they were supported are summarized in Table 6. The results indicate that, contrary to prior research on health generally or negative health behaviors such as smoking, own unemployment is not associated with negative changes

• The analysis here has important

  2018-10-24

  

  The analysis here has important limitations. Many of the policy decisions that would help to constrain unnecessary medical spending lie outside of the control of the California State government. Some, like a law compelling price transparency for pharmaceuticals and medical procedures, are within rel

• br Funding This work was supported by the

  2018-10-24

  

  Funding This work was supported by the Swedish Research Council for Health, Working Life and Welfare (FORTE) under Grant number 2014-0445 for Jenny Torssander, and by the University of Copenhagen for Laust H Mortensen. Body Reports of disrespectful maternity care are emerging worldwide, despi

• We acknowledge several other limitations in our study First

  2018-10-24

  

  We acknowledge several other limitations in our study. First, as we have indicated, there was some selective attrition from the sample between the two interviews. This is not uncommon in panel studies, especially those in which older adults are interviewed (Li et al., 2005). Second, while we have at

• Our first goal therefore is

  2018-10-24

  

  Our first goal therefore is to assess what kinds of CSR initiatives developed by companies have more impact on consumer satisfaction. It might argue that the different nature of CSR initiatives undertaken by a company will have a specific influence on the CSR consumer response mechanism (Carroll, 19

• Surface characteristics and pore structures

  2018-10-24

  

  Surface characteristics and pore structures of adsorbents are the main properties in determining the performance of adsorption, based on equilibrium and rate properties as factors needed for plant design. A high surface area to volume ratio will determine a successful adsorbent as adsorption is a su

• br Data and methodology br Invoice currencies

  2018-10-23

  

  Data and methodology Invoice currencies in the Brazilian foreign trade As mentioned in Section 1, Brazilian exporters were forbidden to receive their payment in domestic currency until 2007, the year our data series begins. From 2007 to 2011, we see that the Brazilian exports’ distribution by

• Our finding that low BRCA expression was

  2018-10-23

  

  Our finding that low BRCA1 GSK461364 manufacturer was not associated with basal-like subtype or worse survival is consistent with the lack of evidence that somatic loss of BRCA1 contributes meaningfully to sporadic breast cancer. Only homozygous, not heterozygous, Brca1 knockout mice develop breast

• Patients diagnosed with lung cancer have

  2018-10-23

  

  Patients diagnosed with lung cancer have a 5year survival rate of XMU-MP-1 cost toxicity is pneumonitis and pulmonary fibrosis which can be life threatening and can affect patients\' quality of life and treatment outcome (reviewed in Abratt and Morgan, 2002). Therefore assessment of response to tre

• We characterized structural disease load using volumetric me

  2018-10-23

  

  We characterized structural disease load using volumetric measures of the caudate, putamen, global gray and global white matter that show sensitivity towards HD-related changes (Tabrizi et al., 2012). These structural markers of disease load were included in a systematic examination of both vorapaxa

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