• br Acknowledgements M M M is the William Dow

  2024-06-03

  

  Acknowledgements M.M.M. is the William Dow Lovett Professor of Neurology and is supported by grants from the Michael J. Fox Foundation for Parkinson's Research, the American Parkinson Disease Association, the New Jersey Health Foundation/Nicholson Foundation, and by the National Institutes of Hea

• Another class of AMPK regulator is peptidyl prolyl cis

  2024-05-31

  

  Another class of AMPK regulator is peptidyl-prolyl cis/trans isomerase (PPIase) NIMA-interacting 1 (Pin1), which binds to a number of proteins and regulates oncogenesis and metabolic diseases (Khanal et al., 2013; Zhou and Lu, 2016). Pin1 has been shown to bind to and inhibit AMPK; therefore, at lea

• Due to its unique histological architecture and blood supply

  2024-05-31

  

  Due to its unique histological architecture and blood supply, the lung is one of the most susceptible organs under uncontrolled systemic inflammatory circumstance [16]. Several studies have reported the anti-inflammatory benefits of metformin in acute lung injury induced by lipopolysaccharide (LPS),

• Kuda et al reported that

  2024-05-31

  

  Kuda et al. (1997) reported that the activity of aminopeptidase A (ApA) but not aminopeptidase B (ApB) nor aminopeptidase N (ApN) was decreased in plasma from patients with Alzheimer's disease (AD). More recently Puertas et al. (2013) reported that the activities of plasma ApA, ApB, ApN and IRAP we

• Another research group assessed pairs

  2024-05-31

  

  Another research group assessed 8503 pairs of middle-aged (anti fungal the twin exposed to surgery had lower scores on cognitive tests in 49% of the pairs. Twins aged 70 and older who underwent hip and knee arthroplasty scored higher on cognitive tests, even higher than those who had not undergone a

• To validate the identified phosphorylation

  2024-05-31

  

  To validate the identified phosphorylation sites in the mouse heart, we analyzed HEK 293T Ketorolac tromethamine salt transfected with Adrb1 based on the hypothesis that protein residues phosphorylated both in vivo and in vitro are more likely to be physiologically relevant. All of the phosphoryla

• The present study showed for the first time that

  2024-05-31

  

  The present study showed, for the first time, that hirsutine, hirsuteine, rhynchophylline, isorhynchophylline, corynoxeine, and isocorynoxeine in yokukansan can inhibit the 5-HT3 receptor current. These data indicate that part of the effect of yokukansan against the behavioral and psychological symp

• Introduction Adenosine monophosphate cAMP is a general

  2024-05-31

  

  Introduction Adenosine 3′,5′-monophosphate (cAMP) is a general-purpose signaling molecule present in most branches of life. Intracellular cAMP levels control diverse cellular functions. In bacteria, cAMP regulates metabolism by activation of the catabolite activator protein (CAP), also known as cAM

• The second evidence comes from the results

  2024-05-31

  

  The second evidence comes from the results obtained by patch-clamp recordings carried out at the endplate region of isolated mouse FDB fibers, where adenosine and the P1R agonist NECA significantly affected the NPo, the open frequency and the time constant τ of the adult nAChR channels. It is genera

• br Conclusions and clinical relevance Astrogliosis and an in

  2024-05-31

  

  Conclusions and clinical relevance Astrogliosis and an increase in ADK is a pathologcial hallmark of epilepsy. The consequence of increased ADK in the epileptic CRA-024781 is a decrease in the ambient adenosine tone and A1R activity. As a result, systemic administration of A1R agonists or ADK inh

• The sequence of our reconstructed Anc is

  2024-05-31

  

  The sequence of our reconstructed βAnc is inferred based on probabilities, and the estimated probability of inferring the actual ancestral sequence is the product of the posterior probabilities for each site within the reconstructed sequence. Although the posterior probabilities (PP) for the majorit

• Introduction Dementia is a common disease

  2024-05-31

  

  Introduction Dementia is a common disease in the elderly, and a significant source of disability, healthcare spending, and long-term care admissions. There is evidence to suggest that testosterone plays a role in cognitive functioning, and lower serum levels correlate with higher amyloid deposits (

• Taniyama et al reported a female with infertility

  2024-05-31

  

  Taniyama et al. reported a female with infertility who had a homozygous T-to-A transversion at nucleotide position g.2472 in exon 3 of the CYP17A1 gene (mutation Y201N) and decreased 17-hydroxylase and 17,20-lyase activities of Methotrexate receptor was initiated using dexamethasone to control adre

• Suspecting that ACL might regulate the expression or

  2024-05-30

  

  Suspecting that ACL might regulate the expression or activity of myogenic transcription factors, Das knocked down MyoD and found that such intervention abolished the effect of ACL on fast MyHC expression and that, conversely, MyoD overexpression partially rescued reduced fast MyHC expression caused

• br Materials and Methods br Results br

  2024-05-30

  

  Materials and Methods Results Discussion 15-HETE is a predominant eicosanoid in pulmonary vascular remodeling, and it could promote hypoxia-induced PAH via its involvement in the regulation of proliferation and cell cycle progression in PASMCs. To understand its role in HPH, we have previou

15406 records 115/1028 page Previous Next First page 上5页 111112113114115 下5页 Last page