• The present study indicates elevated ATX activity as a

  2023-09-19

  

  The present study indicates elevated ATX activity as a highly sensitive and specific biomarker to differentiate ICP from other pregnancy-related liver disorders or pruritic dermatoses. In PCI-32765 to the current gold standard for diagnosis, total fasting serum bile salt levels, ATX appeared as a v

• br Discussion In our current study we demonstrated that

  2023-09-19

  

  Discussion In our current study, we demonstrated that both the metastatic and recurrent ovarian cancer tissues expressed lower levels of p62 when compared with the patient-matched primary tumor samples. High sh4 levels of p62 were associated with long progression-free survival of patients with o

• shows the complexes resulting from interaction of the propos

  2023-09-19

  

  shows the complexes resulting from interaction of the proposed anion receptors with the anions F, Cl, NO, and SO. No imaginary frequency was observed for the optimized complexes indicating the complexes are in potential minima and they are not transition state structures. summarizes the calculate

• shows the complexes resulting from interaction of the propos

  2023-09-19

  

  shows the complexes resulting from interaction of the proposed anion receptors with the anions F, Cl, NO, and SO. No imaginary frequency was observed for the optimized complexes indicating the complexes are in potential minima and they are not transition state structures. summarizes the calculate

• br HMG proteins mobile modulators of chromatin structure

  2023-09-19

  

  HMG proteins: mobile modulators of chromatin structure and cellular phenotype The term “High Mobility Group” was originally coined for the HMG proteins because of their unusual solubility properties, their small size and their rapid mobility, relative to other chromatin proteins, during gel elect

• Recently a Phase III study demonstrated that alectinib the s

  2023-09-18

  

  Recently, a Phase III study demonstrated that alectinib, the second-generation ALK inhibitor, might have a better response to ALK-rearrangement patients than crizotinib [10]. Should alectinib replace crizotinib as the frontline treatment for ALK-rearranged patients? Or should those patients be treat

• Further examination of these vmat IR cells shows that they

  2023-09-18

  

  Further examination of these vmat-IR cells shows that they are also positive for vimentin (vim-IR) (Fig. 3A). However, within any one cell there may be a region of weaker vmat-IR, suggesting sub-cellular localization. As also shown in Fig. 3B and C not all vim-IR cells are vmat-IR suggesting that th

• br ABCA and cancer drug

  2023-09-18

  

  ABCA2 and cancer drug response Overall, the expression of ABC transporters has been linked with multidrug resistance phenotypes through the efflux of drugs via ATP-dependent transport. For example, 13 distinct transporters (ABCA2, ABCB1, ABCB4, ABCB11, ABCC1–6 ABCC10, ABCC11 and ABCG2) have been

• br Methodology In this paper mechanical properties of G acti

  2023-09-18

  

  Methodology In this paper, mechanical properties of G-actin are examined. To do so, three different external tensile loads are exerted to the protein. As illustrated in Fig. 1, Arp2/3 complex binds to the one sides of mother Anastrozole and leads to the growth of a new daughter filament at a dis

• It has been suggested that the suppression of

  2023-09-18

  

  It has been suggested that the suppression of 5-LOX could promote apoptotic signaling pathways in cancers [6]. However, the role of 5-LOX in modulating apoptotic factors and neutrophil activation during ANP has not yet been evaluated. In this study, we aimed to evaluate the expression of 5-LOX in pa

• PFI-2 receptor For the TSH receptor signaling

  2023-09-18

  

  For the TSH receptor, signaling at the Golgi/trans-Golgi network appears required for both rapid effects of TSH − such as PFI-2 receptor depolymerization, which is implicated in thyroglobulin reuptake and, thus, thyroid hormone release − and late ones, such as those on gene transcription. Continued

• Knowledge about adipose tissue has evolved considerably

  2023-09-18

  

  Knowledge about adipose tissue has evolved considerably over the last two decades. Always been described as an inert tissue having the function of stocking lipids, adipose tissue is now recognized as a real organ with both metabolic and endocrine functions secreting various factors into the blood to

• Previously we have detected the expression of APJ receptor o

  2023-09-18

  

  Previously, we have detected the expression of APJ receptor on stomach projecting enfuvirtide in DMV, in addition, icv administration of apelin-13 induced a remarkable c-Fos activation in those cells which were previously marked by a retrograde neuronal tracer fast blue (Birsen et al., 2016). Moreo

• The subnuclear localizations of redox

  2023-09-18

  

  The subnuclear localizations of redox regulators is also largely unknown. The potential role of thiol reductases as transcription regulators or DNA repair molecules may suggest an association to DNA. In this way, the presence of a zinc finger domain potentially involved in protein/DNA interactions o

• br Acknowledgments br Protein microarrays were developed

  2023-09-18

  

  Acknowledgments Protein microarrays were developed to provide miniaturized high-throughput tools to study protein function, Teicoplanin and post-translational modifications. Just a few years ago, the seminal work performed in Stuart Schreiber's laboratory at Harvard University () and at Michae

15429 records 247/1029 page Previous Next First page 上5页 246247248249250 下5页 Last page