• The lanthanide series of chemical elements

  2023-10-16

  

  The lanthanide series of chemical elements comprises the fifteen metallic chemical elements with atomic numbers 57 through 71, from lanthanum to lutetium. Though originally described as ‘‘rare earths’’ because of their natural occurrence as metal oxides, they are not particularly rare. The lanthanid

• br Conclusion Our study of late

  2023-10-16

  

  Conclusion Our study of late-life depression provides evidence of genotype-specific associations between depression and ACE methylation, as well as inverse correlations between ACE methylation and cgrp antagonist secretion. These findings highlight the potential need to consider methylation level

• The first natural product described as LO

  2023-10-16

  

  The first natural product described as 5-LO inhibitor was the polyphenol nordihydroguaiaretic NHS-LC-Biotin from the Mexican dessert plant Larrea divaricata in 1981 (Bokoch and Reed, 1981), short after the initial identification of 5-LO in 1979 (Borgeat and Samuelsson, 1979). Long time before mPGES

• Introduction Dementia is a common disease in

  2023-10-16

  

  Introduction Dementia is a common disease in the elderly, and a significant source of disability, healthcare spending, and long-term care admissions. There is evidence to suggest that testosterone plays a role in cognitive functioning, and lower serum levels correlate with higher amyloid deposits (

• Among the most important Ca

  2023-10-16

  

  Among the most important Ca regulatory mechanisms are the Plasma Membrane Calcium ATPase (PMCA) and Sarcoplasmic Reticulum Calcium ATPase (SERCA). These pumps belong to the family of P-ATPases, which share the formation of an acid-stable phosphorylated intermediate as part of their reaction cycle. P

• KW-6002 receptor In addition to pH regulation by ion counter

  2023-10-16

  

  In addition to pH regulation by ion (counter-) fluxes, acidification is regulated by the abundance of V-ATPase on organelles, by the pumping activity of the complex and by proton leakage. In yeast, the V-ATPase VO subunit a is the only subunit expressed in two isoforms termed Stv1p and Vph1p. V-ATPa

• br Experimental section br Competing interests br Author s

  2023-10-16

  

  Experimental section Competing interests Author's contributions Acknowledgement This research is partially supported by a seed fund for the Center for Drug Discovery and Translational Research (LS) and a research grant by Fujifilm (VPS and LS). The Sponsors played no roles in study desig

• Liproxstatin-1 The tumor suppressor function of LOX in

  2023-10-16

  

  The tumor-suppressor function of 15-LOX-2 in normal prostate epithelial cells may be explained by the induction of replicative senescence [14,15]. Thus, 15-LOX-2 is overexpressed in age-dependent prostatic hyperplasia, but cell senescence may hinder progression to malignant transformation. Notwithst

• To better illustrate the involved neuronal postganglionic pa

  2023-10-13

  

  To better illustrate the involved neuronal postganglionic pathways, central apelin-13 injection was performed in rats received peripheral preadministration of NOS inhibitor L-NAME, sympatholytic agent guanethidine and/or muscarinic receptor agonist bethanechol. Compared with the rats received vehicl

• AP activity is increased by

  2023-10-13

  

  AP-1 activity is increased by MAP kinase stimulation in different cell types (Whitmarsh and Davis, 1996), while MKP-1, the enzyme that catalyzes the dephosphorylation and inactivation of MAP kinases in the nucleus, inhibits AP-1 (Rössler et al., 2008, Rössler and Thiel, 2009, Mayer et al., 2011, Thi

• Recently whey products have been added to nutritional

  2023-10-13

  

  Recently, whey products have been added to nutritional beverages to boost their antioxidant capacity. Supplementation of a lemon drink with 1% WP hydrolyzed by subtilisin increased the antioxidant activity of the beverage from 0.75 to 7.79 mmol of TE/L (Athira et al., 2014). In addition, a flavored

• The AT hook motif is highly conserved in

  2023-10-13

  

  The AT-hook motif is highly conserved in evolution from bacteria to humans and is found in one or more copies in a large number of other, non-HMGA, proteins, many of which are transcription factors or are involved in chromatin remodeling [8]. For example, AT-hook peptide motifs are essential compone

• Seliciclib br Acknowledgments br Introduction Angiotensin II

  2023-10-13

  

  Acknowledgments Introduction Angiotensin II (AngII) is among the most potent vasoactive substances produced in humans. Its effects are numerous, from vasoconstriction to control of fluid and electrolytes balances. Many of the physiological and pathological effects of AngII are mediated by the

• The first and the best

  2023-10-13

  

  The first and the best-characterized mechanism of receptor-dependent internalization of Aβ is mediated via the α7-nicotinic 327 2 receptor [82]. Lipoprotein receptor protein represents the second best-studied route that facilitates the uptake of Aβ by neurons, involving additional molecules such as

• Overexpression of AR in a transgenic

  2023-10-13

  

  Overexpression of AR in a transgenic mouse model leads to a capsular cataract phenotype involving proliferation and formation of a fibrotic plaque of cells reminiscent of cells at the posterior CL 316243 disodium salt in PCO [17]. To investigate the molecular mechanism that could link AR expression

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