• GPR has been implicated in neuropathic and inflammatory pain

  2022-07-19

  

  GPR55 has been implicated in neuropathic and inflammatory pain (Staton et al., 2008) and bone remodeling (Whyte et al., 2009). Thus delineating the pharmacology of this receptor and the discovery of selective agonists and antagonists merits further study and could lead to new therapeutics. Acknow

• Several previous reports have demonstrated that epithelial c

  2022-07-19

  

  Several previous reports have demonstrated that epithelial cell migration is important in promoting mucosal repair after damage caused by DSS and nonsteroidal anti-inflammatory drugs [33], [34], [35]. Cell migration is coordinated by many factors, including fibronectin and its receptor integrin α5,

• No other lacZ mutant showed a

  2022-07-19

  

  No other lacZ mutant showed a marked difference in mutation rate between fpg and fpg backgrounds (that is, rates were comparable between HS101 and CSH1191, HS102 and CSH1192, etc.). The number of reversion mutants was much higher in HS1194 than in any other fpg strain. The inclusion of the pTRC99a p

• The mechanisms by which NEIL

  2022-07-19

  

  The mechanisms by which NEIL1 and NEIL3 excise bulky adducts and unhook ICLs are unclear. Structures of NEIL1 are available only in complex with DNA containing small lesions 79., 80., 81., and the single available structure of NEIL3 lacks DNA (Figure 5D,E) [73]. Nonetheless, comparison of the two st

• In contrast to UDG SMUG exhibits dramatically lower product

  2022-07-19

  

  In contrast to UDG, SMUG1 exhibits dramatically lower product yield in its excision of U, and this is not dependent on sequence context. Though we cannot rule out that a small amount of the product is derived from a duplex contaminant, our extensive purification techniques limit the amount of contam

• br Functional organization of postsynaptic glutamate recepto

  2022-07-19

  

  Functional organization of postsynaptic glutamate receptors Downstream effects of glutamate receptor positioning Mechanisms underlying the subsynaptic positioning of glutamate receptors Conclusions and future prospects The molecular organization of synapses is undoubtedly a critical dete

• Tail group SAR of the imidazole

  2022-07-19

  

  Tail group SAR of the imidazole derived analogs is shown in . The previous SAR study from the discovery of AMG 837 revealed that a simple un-substituted meta-biphenyl tail group was less favorable in terms of potency. Efforts to introduce polarity to the tail group were not successful. When a methyl

• The intestinal epithelium is the

  2022-07-19

  

  The intestinal epithelium is the first line of defense against pathogens and noxious agents and exerts a range of physiological activities, including digestion and ABT-737 of nutrients. The intestinal wall consists of a series of finger shaped protrusions called villi and invaginations known as cry

• br Introduction Hepatocyte injury initiates and facilitates

  2022-07-19

  

  Introduction Hepatocyte injury initiates and facilitates inflammation in the course of liver disease progression. Thus, understanding the regulatory basis for sensing and responding to damage-associated inflammatory processes in the liver’s parenchymal cells is a primary issue in liver pathophysi

• br Introduction In addition to

  2022-07-18

  

  Introduction In addition to glucose, which is the foremost stimulator of insulin secretion in beta-cells, other nutrients such as free fatty acids (also called non-esterified fatty acids, NEFA) contribute to glucose-stimulated insulin secretion (GSIS). Glucose triggers the processes leading to in

• The canonical tumor suppressor p has also been implicated

  2022-07-18

  

  The canonical tumor suppressor p53 has also been implicated as a transcriptional mediator of ferroptotic death (Jiang et al., 2015, Tarangelo et al., 2018, Wang et al., 2016, Xie et al., 2017). Specifically, p53 negatively regulates transcription of SLC7A11, the cystine-glutamate antiporter (Xc-) (J

• The other type of cell death that occurs in activated

  2022-07-18

  

  The other type of cell death that occurs in activated T src inhibitor is caused by growth factor withdrawal following TCR-mediated activation, whereby most of the activated T cells die by apoptosis following the eradication of bacteria during an acute infection in order to reduce the level of cytoki

• Recently the classical view of the compartmentalization of t

  2022-07-18

  

  Recently, the classical view of the compartmentalization of the plant isoprenoid metabolism has been re-evaluated, following the demonstration of the partial peroxisomal localization of the mevalonic paricalcitol sale (MVA) pathway, generally regarded as cytosolic. Using GFP-tagging approaches, the

• In the present study VTE

  2022-07-18

  

  In the present study, VTE recurrence occurred in a non-cancer patient during edoxaban administration, representing recurrence rates of 1.7% in non-cancer patients and 0.8% in all patients. In a sub-analysis of cancer patients [27] and the main analysis [19] in the HOKUSAI-VTE trial, recurrent VTE oc

• The molecular mechanisms underlying VSMC ETB receptor upregu

  2022-07-18

  

  The molecular mechanisms underlying VSMC ETB receptor upregulation have been studied after 24–48h organ culture in both coronary and cerebral arteries. The increased expression of contractile ETB receptor at these time points has been shown to depend on transcriptional mechanisms and PKC and the ext

15845 records 388/1057 page Previous Next First page 上5页 386387388389390 下5页 Last page