• br Neural circuits that control hunger br Ghrelin cognitive

  2021-12-18

  

  Neural circuits that control hunger Ghrelin & cognitive control of feeding Ghrelin is a 28 amino Epalrestat orexigenic peptide that stimulates food intake in rodents and patients (Andrews, 2011, Cummings, 2006, Horvath et al., 2001, Müller et al., 2015, Nakazato et al., 2001, Tschöp et al., 2

• br Conclusions GPCRs are versatile

  2021-12-17

  

  Conclusions GPCRs are versatile signaling molecules regulating almost all physiological processes, including energy homeostasis and glucose homeostasis.105, 106 They also prove to be important therapeutic targets. Drugs targeting GPCRs account for 30% of current pharmaceutical sales. GPR40 is a m

• In various models histamine has been shown to induce chemota

  2021-12-17

  

  In various models, histamine has been shown to induce chemotaxis. This was first appreciated over 40 years’ ago in studies with eosinophils (Clark et al., 1977). At that time, only histamine H1 and histamine H2 receptors were recognized and studies with ligands to these receptors indicated that neit

• A complimentary approach with Per Luc cells exposed

  2021-12-17

  

  A complimentary approach with Per2:Luc Butyrolactone 3 exposed to hypoxia as well as with mBmal1:Luc circadian reporter cells in which we overexpressed variants of HIF-1α and HIF-2α revealed that hypoxia and HIFs can not only shorten the period but also decrease the amplitude of the clock (Figures 2

• Recently anti tumor or antiviral strategies using RNAi

  2021-12-17

  

  Recently, anti-tumor or antiviral strategies using RNAi for both gene silencing and innate-receptor activation were designed; one mechanism of these strategies is activating the intracellular retinoic acid–inducible gene I protein (RIG-I). 5′-Triphosphate RNA (3p-small interfering RNA [siRNA]) is th

• Barthi et al previously showed that curcumin

  2021-12-17

  

  Barthi et al.[43] previously showed that curcumin inhibits IKK complex activity and thus IκBα phosphorylation as well as the p65 nuclear translocation. Those data are in agreement with our results obtained by gel shift assays using GSTP1-1 promoter and consensus NF-κB probes. Moreover, luciferase ac

• Some biguanides can cross the mitochondrial membrane and inc

  2021-12-17

  

  Some biguanides can cross the mitochondrial membrane and increase L-lactate formation by inhibiting oxidative formula weight calculator [34]. On the other hand, it has also been reported that levels of fasting plasma lactate in T2DM patients are similar regardless of whether or not metformin is admi

• br Material and methods br Results

  2021-12-17

  

  Material and methods Results The search for proteins selectively expressed in pancreatic islet MHC class II antigen (45-57) [Homo sapiens] in the Human Protein Atlas (HPA) yielded 27 hits, including well-known islet cell markers such as insulin, glucagon and pancreatic polypeptide (Table 1).

• There is sufficient evidence to

  2021-12-17

  

  There is sufficient evidence to indicate that kisspeptin plays a role in regulating sheep reproduction. However, the molecular mechanism by which kisspeptin regulates GnRH crth2 receptor and reproduction has remained unclear. Therefore, in this study on GnRH in sheep, the promoter region of GnRH wa

• It is important to clarify whether the

  2021-12-17

  

  It is important to clarify whether the decrease in USV after administration was secondary to the central depressant actions of the test compounds. Several reports have addressed the possibility that central depressant actions such as motor incoordination or changes in body temperature might affect U

• FPG had no consistent activity in reducing G T

  2021-12-17

  

  FPG-2 had no consistent activity in reducing G→T transversions. Gao and Murphy [2] earlier reported that FPG-2 had a limited amount of activity in vitro on depurinated, UV-treated, and methylene-blue-treated DNA (but not on 8-oxo-G-containing oligonucleotides). FPG-2 contains the N-terminal domain a

• LFFs associating with green algae utilize polyols therefore

  2021-12-17

  

  LFFs associating with green algae utilize polyols; therefore, we hypothesize that at least one polyol transport system is conserved in LFFs and it is required for the lichenization events that occur widely and independently in Ascomycota. Thus, the present study aimed to first evaluate phylogenetic

• Among the various delivery strategies in the

  2021-12-17

  

  Among the various delivery strategies in the field of nano-DDS, developing smart targeted nanocarriers has long been a research focus for pharmaceutical scientists11., 12.. The ideal drug delivery outcome must be precisely delivering the therapeutic agents to their sites of action, especially for an

• The association between mental disorders

  2021-12-17

  

  The association between mental disorders and smoking was firmly established, and their inter-relationship was due to the reciprocal causal effects (Tjora et al., 2014). Previous research found that negative affect and the urge to smoke as well as the urge to smoke and nicotine dependence had signifi

• br The hippocampus and spatial

  2021-12-17

  

  The hippocampus and spatial memory Numerous lines of evidence have implicated the rodent hippocampus in spatial forms of learning and memory (O’Keefe and Nadel, 1978). For example, hippocampal lesions produce robust and reliable deficits on spatial memory tasks such as the Morris watermaze in bot

15483 records 481/1033 page Previous Next First page 上5页 481482483484485 下5页 Last page