• br Conclusions br Acknowledgments This work was financially

  2021-10-15

  

  Conclusions Acknowledgments This work was financially supported partly by Shanghai Pujiang Talent Project (No.: 08PJ14017), the National Natural Science Foundation of China (Nos.: 20771029 and 91013001) and Shanghai Leading Academic Discipline Project (No. B108). Soluble guanylate cyclase (

• br GSNOR activity and functions The identification of the en

  2021-10-15

  

  GSNOR activity and functions The identification of the enzyme responsible for GSNO decomposition dates back to 1998, when Jensen and colleagues described an NAD(P)H-dependent GSNO catabolizing activity in cytosolic fractions obtained from rat liver [16]. Upon purification, they identified this en

• In addition during the preparation

  2021-10-15

  

  In addition, during the preparation of this manuscript, Oka et al. [7] demonstrated that LPA acts as receptor ligand for GPR35 and that LPA is more potent than KYNA in eliciting a calcium mobilization (EC50: 30nM vs. 39μM for LPA and KYNA, respectively). Other endogenous GPR35 ligands, therefore, mi

• br A selective inhibitor of mammalian histone deacetylase tr

  2021-10-15

  

  A selective inhibitor of mammalian histone deacetylase, trichostatin A, reduces GnRH mRNA expression Epigenetic mechanisms controlling GnRH expression have been reported, and these mechanisms may be involved in the development and maturation of GnRH neurons in the brain (Gan et al., 2012, Kurian

• Based on the molecular weights of glutamate g mol and

  2021-10-15

  

  Based on the molecular weights of glutamate (147.13 g/mol) and MSG (169.111 g/mol), the amount of free glutamate intake obtained in this study was equivalent to 297 mg MSG/d and 370 mg MSG/d for children and adults, respectively. Several previous studies have assessed population intake of MSG from f

• Recently several studies addressed cytological and

  2021-10-14

  

  Recently, several studies addressed cytological and biochemical features of oocyte aging. It was reported that cytological changes associated with the mammalian post-ovulatory oocyte aging include chromatin disorganization, abnormal meiotic spindle location or its disruption, partial exocytosis of c

• This study introduces a mouse model carrying the

  2021-10-14

  

  This study introduces a mouse model carrying the point mutation R258W in Ffar1, which abolishes the stimulation of insulin secretion in response to long chain fatty acids. The minimal genetic alteration mirrors the human situation and has the advantage over conventional knockout/congenic mouse model

• FBPase deficiency is a very rare inborn error

  2021-10-14

  

  FBPase deficiency is a very rare inborn error of fructose Cyclic di-GMP of autosomal recessive inheritance. This disorder usually occurs in the first year of life through ketotic hypoglycemia and lactic acidosis triggered by catabolic episodes such as prolonged fasting or febrile infections (Steinm

• FXa is a vitamin K dependent serine protease consisting of

  2021-10-14

  

  FXa is a vitamin K-dependent serine protease consisting of two chains linked by a disulfide bridge. The heavy chain contains 303 Clonidine HCl and the light chain has 139 amino acids. The catalytic triad comprised of Ser195, His57, and Asp102  exhibits the trypsin-like β-barrel structure [12]. The

• A pyrimidine class of compounds

  2021-10-14

  

  A pyrimidine class of compounds is of enormous interest within anti-HIV drug discovery process for several decades, as pyrimidine based DABOs class [7], DAPYs class [8] are well known as NNRTIs as well as NRTIs. However, the overall role of a pyrimidine class of heterocycles in anti-HIV drug discove

• INF39 australia br Acknowledgments The breast cancer

  2021-10-14

  

  Acknowledgments The breast cancer laboratory is supported by the Australian National Health and Medical Research Council (NHMRC) grants no. 1016701, no. 1024852, no. 1086727; NHMRC IRIISS; the Victorian State Government through VCA funding of the Victorian Breast Cancer Research Consortium and Op

• MDL800 receptor The strict control of Spi

  2021-10-14

  

  The strict control of Spi1 expression is critical for proper myeloid cell fate determination, and genetic or epigenetic changes in the Spi1 gene frequently contribute to the leukemogenesis in mice and human. It is has been shown that Spi1 expression is frequently downregulated in human AML patients

• A second site of histone core domain acetylation that that

  2021-10-14

  

  A second site of histone core domain acetylation that that has been observed on newly synthesized histones is histone H4 lysine 91 [34]. H4 lysine 91 lies along the interface between the H3/H4 tetramer and the H2A/H2B dimers. In fact, H4 lysine 91 normally forms a salt bridge with an aspartic Epiand

• Mammals adapt to prolonged periods of food scarcity by

  2021-10-14

  

  Mammals adapt to prolonged periods of food scarcity by releasing FFAs from adipose tissue and transforming them into energy-rich ketone bodies that are used as fuel by brain, muscle, and other organs (Kersten, 2014, Grabacka et al., 2016). Ketogenesis occurs primarily in hepatocytes, but its rate is

• PF-06463922 br Materials and methods br Results br

  2021-10-14

  

  Materials and methods Results Discussion Both EMT of the tubular epithelial PF-06463922 and the activation of fibroblasts are critical factors in the pathogenesis and progression of renal interstitial fibrosis. Accumulating evidence implicates EMT in the onset and pathogenesis of renal int

15742 records 537/1050 page Previous Next First page 上5页 536537538539540 下5页 Last page