• br STAR Methods br Acknowledgments We would like

  2021-10-11

  

  STAR★Methods Acknowledgments We would like to thank Dr. Xiping Cheng for help with the immunohistochemistry staining, Qi Su for help with gene expression analysis, and Dr. Chaoying Liang at the UTSW Genomics Microarray Core facility for assistance on RNA-seq. W.-H.L. was supported by grant awa

• Recently several dual GLP GIP receptor agonists

  2021-10-11

  

  Recently, several dual GLP-1/GIP receptor agonists have been developed as a treatment of type II diabetes. These peptides can activate both the GLP-1 and the GIP receptor. Such dual receptor agonists are superior compared to single GLP-1 analogues such as liraglutide (Finan et al., 2013). Previously

• The molecular nature of these putative

  2021-10-11

  

  The molecular nature of these putative Ca2+ Diclofenac Sodium synthesis is at present unknown. Apart from the NSVDC channel, which is permeable to Ca2+ [27], [15] functional Ca2+ channels have been identified in patch clamp experiments [28]. These channels, which were characterized as B-channels, s

• The ETB receptor has been shown to decrease sodium

  2021-10-11

  

  The ETB receptor has been shown to decrease sodium transport in the renal medullary collecting duct and medullary thick ascending limb of Henle10, 11, 12, 13, 18. However, both inhibitory and stimulatory effects of endothelin have been reported in the proximal tubule16, 47, 48, 49. In the rat, endot

• br Histamine and glycaemia Histamine

  2021-10-11

  

  Histamine and glycaemia Histamine is involved in a wide variety of pathophysiological events mostly related to the inflammatory response through four receptors, namely H1-4Rs. The first studies of DNQX disodium salt and diabetes date back to the 1950s. Since that time the involvement of histamin

• Hepatitis C virus HCV is a frequent cause of

  2021-10-11

  

  Hepatitis C virus (HCV) is a frequent cause of infectious chronic hepatitis. Unlike hepatitis A and B, there is no vaccine to prevent hepatitis C infection yet. According to WHO, around 200 million people are infected with HCV worldwide [1], in addition to three to four million newly infected patien

• The mD gene obtained from Dr Dimiter

  2021-10-11

  

  The mD1.2 gene obtained from Dr. Dimiter S. Dimitrov was inserted into a pComb3X vector. The transcription and translation of pComb3X plasmid in cells is inhibited by rifampicin, which binds to bacterial DNA-dependent RNA polymerase. However, in the strain BL21 (DE3) expression system, there is ov

• br Experimental br Results br

  2021-10-11

  

  Experimental Results Discussion The use of Dex-BSA asa membrane-limited glucocorticoid has been met with some skepticism, mainly for its assumed instability. Here we provide conclusive evidence that Dex-BSA is stable in solution over an extended period of time and at high temperature (i.e.,

• OSMI-1 Cichlasoma dimerus as most teleost

  2021-10-11

  

  Cichlasoma dimerus, as most teleost fish species, present neurons expressing GnRH3 (Pandolfi et al., 2005). As in most OSMI-1 species, the neurons expressing GnRH3 are mainly located in the NOR, although few neurons were detected in the olfactory bulb, ventral telencephalon and the POA (González-Ma

• According to the World Health Organization

  2021-10-09

  

  According to the World Health Organization, the average global intake of fat has increased by 20 g per person over the last half-century [21]. However, not all fats are the same and it is now well established that saturated and unsaturated fats, as well as trans fats, can act in opposing ways to inf

• LiCl australia Some malignant human tumors cells also

  2021-10-09

  

  Some malignant human tumors LiCl australia also express FPRs and respond to bacterial or endogenous agonists by increased motility and growth. For instance, FPRs expressed by human gastric cancer cells, mediate epithelial–mesenchymal transition, cell proliferation, migration, and resistance to apop

• br Declaration of interest br Acknowledgments br This work

  2021-10-09

  

  Declaration of interest Acknowledgments This work was supported by grants from the Polish National Science Centre (PRELUDIUM grant no. 2013/11/N/NZ5/00270) and the European Commission FP7 Project Beta-JUDO (grant number 279 153), European Union EIT Health project DeTecT2D, Swedish Diabetes A

• Accordingly and in animal models

  2021-10-09

  

  Accordingly and in animal models, a high-fat diet rich in CO (CO-HFD) impeded ventricular function and induced cardiac cell death and remodeling, at least, by down-regulating cell antioxidant defense systems and induction of oxidative stress [28], [29], [30], [31]. Interestingly, long chain fatty ac

• Following the discovery of diketo

  2021-10-09

  

  Following the discovery of β-diketo compounds S-1360 [31] and L-731988 [32] as anti-HIV integrase inhibitors, a group of researchers discovered a potent NG,NG-dimethyl-L-Arginine hydrochloride based derivative (1) as the inhibitor of HIV integrase functioning at the 3′-processing and strand transfer

• Another important outcome of reducing hypothalamic HIF in DI

  2021-10-09

  

  Another important outcome of reducing hypothalamic HIF in DIO was the increase in gliosis and hypothalamic inflammation. Both experimental and human studies have shown that hypothalamic inflammation plays an important role in obesity by inducing resistance to anorexigenic signals, such as insulin an

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