• IC261 br Conflict statement br Introduction Prostate cancer

  2021-08-27

  

  Conflict statement Introduction Prostate cancer (PCa) is the second most frequently diagnosed cancer and the second leading cause of cancer death in men after lung cancer [1], [2]. The incidence and mortality rate of prostate cancer are significantly higher in developed countries especially th

• Therefore in this study we determined whether exogenous LTD

  2021-08-27

  

  Therefore, in this study we determined whether exogenous LTD, a potent agonist of both CysLT and CysLT receptors , , induces Oligomycin Complex edema and AQP4 expression in mouse brain; if so, which subtype of the receptors is involved in AQP4 expression in mouse brain and the cultured rat astrocyt

• br Transparency document br Acknowledgments This work was

  2021-08-27

  

  Transparency document Acknowledgments This work was supported by the Ministry of Education, Youth and Sports of the Czech Republic (the National Program of Sustainability I, Grants LO1204 and LO1304), by the Czech Science Foundation (15-17282Y) and by Palacký University Olomouc (IGA_PrF_2017_0

• Calcitriol Recently we have created CRISPR Cas mediated col

  2021-08-27

  

  Recently, we have created CRISPR/Cas9-mediated col14a1a knockout fish to interrogate the function of col14a1a during regeneration using the caudal fin model. Using AFM, we showed that collagen XIV-A transiently acts as a molecular spacer responsible for BM biomechanics possibly by helping laminins i

• The most common adverse events

  2021-08-27

  

  The most common adverse events in relation to udenafil treatment are headache and facial flushing; other possible adverse events are febrile sensation, dyspepsia, and visual disturbances. No severe adverse event related to udenafil has been reported thus far. The adverse event rate recorded in the p

• TAK-875 br Discussion The use of

  2021-08-27

  

  Discussion The use of carp primary cell cultures proved to be a valuable approach to evaluate the piscine immune response. A. hydrophila was a more potent stimulator of NO formation by carp leukocytes compared to commercial LPS often used for leukocyte stimulation (Mustafa and Olson, 1998, Chao e

• Fujimoto et al pointed out that

  2021-08-27

  

  Fujimoto et al. pointed out that RPN2 knockout alleviated the resistance of GC Terfenadine (MKN74 and KATO III) to docetaxel and DDP [23]. Yuan et al. demonstrated that the depletion of RPN2 resulted in the reduction in resistance of GC cells to drugs such as irinotecan, docetaxel, doxorubicin, oxal

• Epac proteins consist of a carboxyl terminal

  2021-08-27

  

  Epac proteins consist of a carboxyl-terminal catalytic region and an amino-terminal regulatory region, which harbors one cAMP-binding domain in Epac1 and two in Epac2 [22], [32], [51]. In the absence of cAMP, the regulatory region covers the CDC25-homology domain and autoinhibits Epac's enzymatic ac

• On the other hand although the cardiovascular

  2021-08-27

  

  On the other hand, although the cardiovascular effects of Epac have been investigated more intensely in recent years [31], there are hardly any studies that suggest or discard a participation of Epac in endothelium-dependent cAMP-induced relaxation. Only our previous results in rat clofibrate contr

• In vitro studies suggest that cPLA

  2021-08-27

  

  In vitro studies suggest that cPLA2α does not show clear preference for the headgroup present at the sn-3 position, although a slight preference for zwitterionic phospholipids such as PC and PE has recently been pointed out [24]. In this regard, mass spectrometry analyses of glycerophospholipid hydr

• Lovastatin australia br Protein protein interactions of LEI

  2021-08-27

  

  Protein-protein interactions of LEI/L-DNase II and the control of cell death Evolutionary tips The serpin inhibitory mechanism is extremely well adapted to evolutionary changes because a single amino Lovastatin australia substitution in the RSL can led to the inhibition of a totally different

• Given that CE plays an essential role in schistosome invasio

  2021-08-27

  

  Given that CE plays an essential role in schistosome invasion, its immunoreactivity and protective potential is of significant interest. The native form of SmCE was found to be poorly immunogenic in immunized mice. An earlier study found that sera from S. mansoni patients have shown the presence of

• Does a universal mechanism for

  2021-08-26

  

  Does a universal mechanism for TLS exist? Our previous studies using the bacteriophage T4 DNA polymerase generated the model provided in Fig. 7 that quantifies the molecular forces influencing key steps in the polymerization pathway during the replication of a non-instructional versus miscoding DNA

• Then we explored the MCLEIA methodology

  2021-08-26

  

  Then, we explored the MCLEIA methodology parameters including precision, accuracy and specificity. In the 0.5–128 ng/mL, the standard curve equation was  = 0.5014 + 1.769 ( was log, was RLU/RLU with a correlation coefficient of 0.9907) (). On the one hand, same sample (0.5, 4.0, 32.0 ng/mL) detecte

• br Authors contributions br Acknowledgements br

  2021-08-26

  

  Authors’ contributions Acknowledgements Introduction Retinoic 5153 synthesis is a key signalling molecule in healthy development and in differentiation of stem cells, albeit uncontrolled levels of retinoic acid can lead to mutagenesis [1]. In eukaryotes retinoic acid is made by oxidation of

15742 records 567/1050 page Previous Next First page 上5页 566567568569570 下5页 Last page