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In addition further study is required to evaluate
2019-06-13
In addition, further study is required to evaluate whether identified mutations influence post-translational modifications because they are important mechanism of transcription factors for regulating normal and leukemic hematopoiesis. Authors\' contributions Conflict of interest Acknowledgm
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Idelalisib demonstrates a dual mechanism of action by
2019-06-13
Idelalisib demonstrates a dual mechanism of action by inhibiting pro-survival signalling pathways [6], and, like other kinase inhibitors, leads to re-localisation of tumour D609 by blocking ingress into and promoting egress out of the lymph node into the blood. Release from the protective lymph envi
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A number of studies have
2019-06-12
A number of studies have shown that zoledronic equol has the ability to potentiate effects of anti-tumor agents such as doxorubicin [21] or everolimus [22]. In a recent paper the combination of chemotherapy with a single infusion of 4mg zoledronic acid in patients with breast cancer was shown to re
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In this issue of the Shoja et al characterize
2019-06-12
In this issue of the , Shoja et al characterize the antimicrobial susceptibility pattern, resistance mechanisms, and typing of carbapenem-resistant (CRAB) isolates obtained from burn patients from a single center in Iran. They found that the rate of CRAB was high (92.5%) among burn patients. The mo
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etizolam vendor br Conclusion Accumulating clinical data sug
2019-06-12
Conclusion Accumulating clinical data suggest the presence of a genetic component in the pathogenesis of AF. In addition to the gene mutations identified in familial AF, the candidate gene approach and GWAS identified genetic risks in the non-familial form of AF. In multiple Western populations,
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br Discussion Sato et al first reported TCM in and
2019-06-12
Discussion Sato et al. [11] first reported TCM in 1990, and thereafter, numerous cases were reported in the late 2000s. In 85% of the cases, TCM onset was preceded by an emotional or physical stress event, however, in 15% of the cases, the presence of a stress trigger could not be detected [2]. M
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In patients with ovary lesions surgical intervention
2019-06-12
In patients with ovary lesions, surgical intervention play an important role to establish correct diagnosis. First of all, obtaining histologic confirmation of disease by laparotomy is critical in differentiating primary ovarian cancer between metastatic lesions such as gastric cancer to the ovary (
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br Introduction Patients with advanced breast prostate
2019-06-12
Introduction Patients with advanced breast, prostate, lung and colo-rectal cancer frequently develop bone metastases (BMs). These lesions may be asymptomatic or may cause pain, pathologic fractures, malignant hypercalcemia, epidural spinal cord compression and/or shorten survival [1]. The underly
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The standard therapy for chordoma is
2019-06-12
The standard therapy for chordoma is excision. Local recurrence, but not metastasis, is a major determinant of prognosis. Because local recurrence is related to initial surgical margin and intra-operative tumor cell contamination, achieving a safe margin is very important. Boriani [6] reported 153 c
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nk1 receptor Findings from the last major systematic
2019-06-12
Findings from the last major systematic review of the global prevalence of echocardiographic rheumatic nk1 receptor disease showed that the highest calculated regional prevalence was in sub-Saharan Africa (5·7 cases per 1000 people), indigenous people in the Pacific islands, Australia, and New Zeal
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Si en La virgen de los
2019-06-12
Si en La virgen de los sicarios “la vida crapulosa está derrotando GSK212 Supplier la muerte”, y “anda toda ventiada por Medellín día y noche en su afán haciendo lo que puede, compitiendo con semejante paridera, la más atroz [y] este continuo nacer de niños y el suero oral le están sacando canas”, p
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The nutrition support team NST estimated his
2019-06-11
The nutrition support team (NST) estimated his nutritional status and began the intervention. An inadequate calorie intake (due to swallowing difficulty) induced malnutrition in the patient; his bodyweight (BW) loss exceeded 8% in 3 months, his body mass index (BMI) was 21 kg/m2, triceps skinfold th
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In our study acute toxicities were
2019-06-11
In our study, acute toxicities were mild, and there were no Grade 3 or above hematologic toxicities. Only one patient (3.2%) had Grade 3 esophagus toxicity and three patients (9.7%) had Grade 3 lung toxicity. Compared with studies that investigated regimens of oxaliplatin and 5-FU/leucovorin, the pr
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lpa receptor br Materials and methods br Results
2019-06-11
Materials and methods Results Shortening of the QRS duration in 7 and lengthening of the QRS duration in 3 of the 24 patients were observed during RV pacing at a mean pacing lpa receptor length of 346±37ms and 258.3±14.4ms (Fig. 1; Tables 1 and 2). The mean shortening of the QRS duration was
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metabolic enzymes The TP related complications are given in
2019-06-11
The TP-related complications are given in Table 3. Pericardial effusion without tamponade was seen in 2 patients (5.9%) in the TEE-guided TP group and 5 (8.8%) in the fluoroscopy-guided group. There was no pericardial tamponade in the TEE-guided group and only one patient experienced tamponade in th
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