• Lanabecestat (AZD3293) BACE1 Research Workflow

  2026-08-22

  Build a practical Lanabecestat workflow that connects amyloid-beta production inhibition with synaptic-function measurements. This guide emphasizes exposure titration, paired biochemical and optical assays, and troubleshooting grounded in the finding that moderate BACE1 inhibition can reduce Aβ without necessarily disrupting synaptic transmission.

• GSK3 Inhibition as Host-Directed TB Therapy

  2026-08-22

  The 2024 iScience study identifies glycogen synthase kinase 3 inhibition as a host-directed strategy for restricting intracellular Mycobacterium tuberculosis growth. By combining chemical screening, genetic perturbation, macrophage infection models, and phospho-proteomics, the work connects GSK3 signaling with pathogen-driven macrophage dysfunction and apoptosis.

• U 46619: TP Receptor Agonist Guide

  2026-08-21

  U 46619, also called 11,9 epoxymethano-prostaglandin H2, is a synthetic TP-receptor agonist used to model platelet activation and vascular responses. Product-reported EC50 values distinguish early platelet shape change and myosin light-chain phosphorylation from later serotonin release, aggregation, and fibrinogen-receptor binding.

• Digoxin Workflows for Cardiac and Viral Research

  2026-08-20

  Digoxin supports two distinct research programs: Na+/K+ ATPase-driven cardiac contractility modulation and cell-selective inhibition of chikungunya virus infection. This practical guide connects model selection, dosing, controls, and troubleshooting while separating product-backed findings from workflow recommendations.

• Bromodomain Inhibitor (+)-JQ1: BET Workflows

  2026-08-20

  Bromodomain Inhibitor, (+)-JQ1 converts BET biology into practical workflows for apoptosis, chromatin, cancer combination, inflammation, and reproductive studies. This guide links BRD4-focused mechanism with assay design, dosing controls, and troubleshooting strategies that improve reproducibility.

• CHI3L1-IN-5: CNS Neuroinflammation Workflows

  2026-08-19

  CHI3L1-IN-5 (Compound Z17) enables a paired workflow: measure CHI3L1-mediated NF-κB suppression while testing astrocyte Aβ uptake and lysosomal recovery. Its CNS-oriented physicochemical profile makes it useful for mechanism-led neuroinflammation studies, provided exposure, vehicle, and functional rescue are interpreted separately.

• PX-478 and Prenatal Hypoxia-Induced ASD-Like Behavior

  2026-08-19

  A 2024 rat study examined whether PX-478-mediated HIF-1α inhibition could reduce autism-like behavioral and hippocampal abnormalities after prenatal hypoxia. The findings connect improved behavior with reduced hippocampal HIF-1α, increased PTEN, lower circulating VEGF, and treatment-timing-dependent safety signals.

• T0070907: Practical PPARγ Antagonist Guide

  2026-08-18

  T0070907 is a nanomolar PPARγ antagonist for separating receptor-dependent transcription from downstream phenotypes in adipogenesis, inflammatory macrophage, and cancer models. This guide translates its covalent mechanism into practical workflows, controls, and troubleshooting strategies for reproducible pathway studies.

• Partial BACE1 Inhibition and Synaptic Function

  2026-08-18

  Satir et al. examined whether moderate β-secretase inhibition can reduce amyloid-beta secretion without impairing neuronal communication. Using primary rat cortical cultures, optical electrophysiology, and three BACE inhibitors, the study found that reductions below 50% preserved synaptic transmission, whereas stronger inhibition was associated with functional suppression.

• Geneticin: Selection and Antiviral Workflows

  2026-08-17

  Geneticin, also called G418 Sulfate, combines dependable neomycin-resistance selection with a distinct application in Dengue virus research. This practical guide connects kill-curve design, stable cell engineering, extracellular-vesicle studies, and assay troubleshooting while separating established evidence from workflow recommendations.

• Annexin V-Cy5/DAPI Apoptosis Kit: Assay Logic

  2026-08-17

  The Annexin V-Cy5/DAPI Apoptosis Kit converts phosphatidylserine exposure and membrane integrity into an interpretable cell-death map. This article connects the assay to P2RX1-driven mitochondrial apoptosis in Ph+ ALL while defining practical controls, readout limits, and workflow decisions.

• AMG 9810 for Reliable TRPV1 Assays

  2026-08-16

  Learn how AMG 9810 (SKU B7018) can improve mechanistic interpretation of calcium influx, CGRP release, viability, and cytotoxicity experiments involving TRPV1. This scenario-based guide covers solvent controls, assay compatibility, workflow parameters, metabolic-stress confounders, and practical product-selection criteria.

• E-64d Workflows for Calpain and Cathepsin Research

  2026-08-15

  E-64d enables intracellular inhibition of calpain and several lysosomal cysteine proteases, making it useful for dissecting platelet activation, apoptosis, lysosomal cell death, and seizure-related injury. This practical guide connects mechanism to experimental workflows, controls, troubleshooting, and interpretation limits.

• InstaBlue Protein Stain Solution Protocol

  2026-08-14

  InstaBlue Protein Stain Solution provides rapid Coomassie Brilliant Blue visualization of protein bands in polyacrylamide gels without fixation, washing, or destaining. It is suitable for routine protein electrophoresis analysis and downstream band excision, but its stated sensitivity should not be treated as a universal quantitative limit or automatically extended to membranes, tissues, or non-gel samples.

• Amphotericin B: Ergosterol-Aware Assay Design

  2026-08-14

  Amphotericin B research is stronger when ergosterol abundance is treated as an experimental variable rather than a background condition. This guide translates a recent Candida study into practical, sterol-aware decisions for fungal infection research, biofilm assays, immune readouts, and model selection.

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